Temozolomide (NSC 362856), DNA Alkylator
Por um escritor misterioso
Descrição
Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects. - Mechanism of Action & Protocol.
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Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide in: Journal of Neurosurgery Volume 99 Issue 6 (2003) Journals
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Temozolomide
Temozolomide (NSC 362856), DNA Alkylator
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